Enlarged prostate is a medical problem in men in which the prostate gland increases in size and creates urinary discomfort. It is one of the most common problems in men of old age that is treatable, and in most cases, the condition is reversible. 

There are various treatment options available for enlarged prostate, starting from simple drugs that can block or inhibit the process of prostate enlargement or the symptoms affecting urinary tract functions. There are minimally invasive laser treatments to completely remove the prostate. Major treatments comprise surgeries of the prostate and urethral region.

LIST OF ENLARGED PROSTATE TREATMENTS

Treatment options for enlarged prostate are decided based on several factors. These include, 

  1. 1. Age of the person
  2. 2. Severity of condition
  3. 3. Health history of the patient
  4. 4. How much prostate is enlarged
  5.  

In some cases, the enlarged prostate condition is asymptomatic, or the patient can tolerate the symptoms without much effort. In this case, the patient can postpone the treatment. 

Treatment options include:

  1. 1. Medications
  2. 2. Injections
  3. 3. Surgical therapies
  4. 4. Laser therapies 
  5. 5. Implants
  6.  

 

  • A. Medical therapy
      1. 1. Alpha-blockers- Silodosin
      2. 2. Alpha-reductase inhibitors 
      3. 3. Antimuscarinics
      4. 4. Combination of alpha-reductase inhibitors and alpha blockers
      5.  
  • B. Injections-  NX-1207 & PRX302
  • C. Surgery

Surgical therapies or minimally invasive treatment for an enlarged prostate include, 

  1. 1. Transurethral -Prostate incision
  2. 2. Transurethral -Prostate resection
  3. 3. Transurethral-microwave thermotherapy (TUMT)
  4. 4. Needle-ablation therapy
  5. 5. Convective vapour energy ablation therapy
  6. 6. Robot-assisted -prostatectomy
  7. 7. Artery embolization in prostate
  8.  

4. Laser therapy

  • HoLEP

  • Greenlight laser therapy
  • Thulium laser therapy
  1. Implants

Prostatic urethral lift- Urethral implants surgically positioned in the prostate region to retract the lobes of the prostate.

DRUGS FOR ENLARGED PROSTATE

  • 1. Alpha-blockers- This class of drugs are used to relax the bladder and prostate muscles by acting on and inhibiting the sympathetic nerve signals.
  • 2. Silodosin- It is an alpha-blocker drug with high selectivity
  • 3. Alpha-reductase inhibitors- This class of drugs lighten the impact of androgen on the prostate by inhibiting the mechanism of testosterone getting converted to DHT.
  • 4. Antimuscarinics- Act on neuromuscular receptors of overactive bladder to get the bladder in normal condition.
  • 5. Combination drugs- Alpha-reductase inhibitors and alpha blockers
  •  

Injection for enlarged prostate

 NX-1207 & PRX302- This injection is administered carefully inside the prostate to get relief from adverse symptoms. It is the latest breakthrough research product that has proven as a novel therapy.

Surgery

Surgical therapies or minimally invasive treatment for an enlarged prostate include, 

Transurethral -Prostate incision

Transurethral -Prostate resection– involves the use of electrocautery to excise part of the prostate. 

Transurethral-microwave thermotherapy (TUMT)

  • 1. Needle-ablation therapy
  • 2. Convective vapour energy ablation therapy- 
  • 3. Robot-assisted -prostatectomy- Is a minimally invasive surgery to remove the enlarged prostate through the use of robotic technology.
  • 4. Artery embolization in prostate- Artery embolization is meant to promote targeted apoptosis (cell death) to prevent growth by embolizing arteries in the prostate.
  •  

Laser therapy

HoLEP- it employs pulsed lasers to cut tissue and cauterise.

  1. 1. Greenlight laser therapy- It is based on a photoselective vaporisation process which uses high-power KTP wavelength.
  2. 2. Thulium laser therapy- This laser therapy to correct enlarged prostate uses a very element, thulium. This is used to provide a continuous flow of laser waves to cut part of the prostate through vaporisation.
  • Implants

Prostatic urethral lift- Urethral implants surgically positioned in the prostate region to retract the lobes of the prostate.

Frequently asked questions

Q1. What is the most common surgery for an enlarged prostate?

TURP is the surgical resection of the prostate through the urethra using a visualization tool, a resectoscope. This surgery is meant to improve urinary tract symptoms and relieve the effect of compression on the bladder by an enlarged prostate. It has been the most effective and most common surgical treatment for enlarged prostate.

Q2. What are the drugs for enlarged prostate?

DRUGS FOR ENLARGED PROSTATE

  • 1. Alpha-blockers- This class of drugs are used to relax the bladder and prostate muscles by acting on and inhibiting the sympathetic nerve signals.
  • 2. Silodosin- It is an alpha-blocker drug with high selectivity
  • 3. Alpha-reductase inhibitors- This class of drugs lighten the impact of androgen on the prostate by inhibiting the mechanism of testosterone getting converted to DHT.
  • 4. Antimuscarinics- act on neuromuscular receptors of overactive bladder to get the bladder in normal condition.
  • 5. Combination of alpha-reductase inhibitors and alpha blockers
  •  

Q3. What are the treatment options for enlarged prostate?

Doctors advise different treatment options based on the severity of the condition, age, size of the prostate, etc. 

  1. A. Drugs to treat enlarged prostate belong to the following classes
    1. 1. Alpha-reductase inhibitors 
    2. 2. Alpha-blockers
    3. 3. Antimuscarinics
    4. 4. Combination of alpha-reductase inhibitors and alpha blockers
    5.  
  2. B. Surgical therapies or minimally invasive treatment for an enlarged prostate include, 
  • 1. Transurethral Prostate incision
  • 2. Transurethral Prostate resection
  • 3. Transurethral microwave thermotherapy (TUMT)
  • 4. Needle ablation therapy
  • 5. Laser therapy- using the element thulium, green light laser, etc.
  • 6. Prostatectomy (robot-assisted) is a minimally invasive method to remove the prostate permanently.
  • 7. Prostatic urethral lift using implants that are placed inside the urethra
  •  

Q4. Is there any permanent cure for an enlarged prostate?

Yes, an enlarged prostate can be cured permanently. Robot-assisted prostatectomy and laser treatment can cure enlarged prostate completely.

Q5. Is it possible to cure an enlarged prostate with a laser?

Yes, there are laser therapies to treat enlarged prostate. Laser therapies involved in correcting enlarged prostate include, HoLEP, greenlight laser therapy, and thulium laser therapy.

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