Research overview

A new combination of 4 drugs has outperformed standard mono-drug therapy for hypertension. According to the QUARTET USA drug trial, the results have been found to be more effective for diastolic blood pressure as compared to systolic blood pressure.

What is Quartet USA?

The term QUARTET USA is derived from quadruple Ultra-low-dose treatment for hypertension. The QUARTET USA is a double-blind, randomized controlled trial on a combination of 4 antihypertensive drugs. The phase III drug trial was successfully carried out for a period of 12 weeks on 591 adults with mild to moderate hypertension. 

Purpose of Quadpill Drug Research

This study has been put forward in accordance with the previous drug trial QUARTET, which was conducted in Australia. The results were found to be significantly similar to the previous study, which ensures the high efficacy of this drug despite different populations. 

What is Quadpill?

Quadpill is the combination of 4 antihypertensive drugs which has been found to be more effective in lowering blood pressure as compared to a single dose of standard antihypertensive drugs. This drug combination is developed to get effective results at low doses. 

What are the constituents of quadpill?

A single quadpill constitute 37.5 mg of irbesartan, 1.25 mg of amlodipine, 0.625 mg of indapamide and 2·5 mg of bisoprolol. 

Research interpretation and results

This comparative study between the quad pill and a standard antihypertensive drug showed that there is a significant decline in blood pressure by 5 mm Hg in the case of quadpill as compared to a single dose of irbesartan (blood pressure lowering drug). 

Research first presented in..

The QUARTET-USA study was presented in the scientific sessions of 2022 at American Heart Association by Mark Huffman, professor of medicine at Washington University School of Medicine, Missouri.

Frequently Asked Questions

What is Quartet USA?

The term QUARTET USA is derived from quadruple Ultra-low-dose treatment for hypertension. The QUARTET USA is a double-blind, randomized controlled trial on a combination of 4 antihypertensive drugs. 

What is Quadpill?

Quadpill is the combination of 4 antihypertensive drugs which has been found to be more effective in lowering blood pressure as compared to a single dose of standard antihypertensive drugs. This drug combination is developed to get effective results at low doses. 

A single quadpill constitute 37.5 mg of irbesartan, 1.25 mg of amlodipine, 0.625 mg of indapamide and 2·5 mg of bisoprolol. 

What are the constituents of quadpill?

Quadpill is developed by mixing 4 drugs which are normally used to lower the blood pressure in the patients with mild to moderate hypertension. The antihypertensive drugs used to make the quadpill include,

  • 1. 37.5 mg of irbesartan 
  • 2. 1.25 mg of amlodipine
  • 3. 0.625 mg of indapamide 
  • 4. 2·5 mg of bisoprolol 
  •  

What is the purpose behind Quadpill USA drug trial?

This study has been put forward in accordance with the previous drug trial QUARTET, which was conducted in Australia. The results were found to be significantly similar to the previous study, which ensures the high efficacy of this drug despite different populations. 

What is the normal blood pressure?

Normal blood pressure count is 120/80. It is spoken as 120 over 80, which means 120 systolic blood pressure and 80 is the diastolic blood pressure. Systolic blood pressure refers to the blood pressure in the arteries when the heart is filled with blood and the heart is beating. This time in the heart cycle is called the contraction of the atrium.

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